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Pulse se din f%C%Brste medieoptr%C%Aden som en d%C%Ase%C%Abner til f%C%A mere lasse marker

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Oxidative stress is increased in diabetes mellitus owing to an increase in the production of oxygen free radicals and a deficiency in antioxidant.
LASSI - Land and Survey Spatial Information. Login / Register. Help. Map. Imagery. Victoria. Search. Build Map. Legend. Address. Address PFI. Coordinates. Biomarkers of oxidative stress present in breath. Reactive oxygen species accelerates four important molecular mechanisms that are involved in oxidative tissue damage induced by hyperglycemia. Advanced glycation end products and receptor-oxidative stress system in diabetic vascular complications. Reactive oxygen species produced from free fatty acids can cause mitochondrial deoxyribonucleic acid damage and impaired pancreatic β-cell function Rachek et al. Enhanced expression of glutathione peroxidase protects islet beta cells from hypoxia-reoxygenation. Journal of Physiology, Vol.

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The Jun kinase pathway is also activated by the pro-inflammatory cytokines, and there is evidence that oxidative stress is involved in β-cell destruction Kaneto et al. Evaluation of selected components in antioxidant systems of blood in patients with diabetes. Oxidative stress and diabetes-associated complications. The decrease of red cell glutathione may be due to its higher rate of consumption, increasing glutathione peroxidase activity or a reduction of pentose phosphate pathway, stimulated by insulin, resulting in lowered glutathione recycle Likidlilid et al. With decreased antioxidant capacity, β-cells are extremely sensitive towards oxidative stress.
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Role of peroxynitrite in the pathogenesis of cardiovascular complications of diabetes. Oxidative stress and beta-cell dysfunction. Ther Apher Dial Vol. The latter can be released into extracellular space Reiter et al. Furthermore, increased glucose can cause rapid induction of the Krebs cycle within the β-cell mitochondria, leading to augmented reactive oxygen species production Newsholme et al. Protein tyrosine nitration in mouse peritoneal macrophages activated in vitro and in vivo: evidence against an essential role of peroxynitrite. Cell Biochem Biophys Vol.
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